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Efek MutagenikEkstrak Etanol Daun Kembang Sungsang (Gloriosa superha L)

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Efficacy of a plant can be caused by chemical compounds contain, on the other hand can cause toxic effects/ Toxic effects of chemicals can be defined as the potential of chemicals to poison the bodies of people who are exposed kembang sungsang (Gloriosa superb Linn) including Colchicaceae families. Plants used empirically for treatment of Gout, diuretic, rheumatism, etc. Mutagenicity is a test to determine the possibility of compounds are mutagens. To see if these plants have the effect of effect of mutagens, mutagenicity tests performed 70% ethanol extract of the leaves kembang sungsang. Mutagenicity studies conducted by the Ames method using five test bacterial strains that have been transferred are: Salmonella typhinurium TA 98. TA 100. TA 1535. TA 1537 and Escherichia coli WP2uvrA with and without metabolic activator S-9. The dose tested 125, 250, 500, 1000, and 2000 µl/ plate. As a negative control was DMSO solution of 100 µl/ plate. The results showed that the mutagenic test 70% ethanol extract of leaves Kembang sungsang, with the addition activator without the addition of 5-9 did not have the effect of mutagens.

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Call Number

Jurnal Kefarmasian Indonesia:1(3):77-82

Publisher

Jakarta : Puslitbang Biomedis dan Farmasi Badan Litbang Kes., 2009

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ISBN/ISSN

2085-675X

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Subject(s)

plants, medicinal

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