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Clinical Test on the Effectivity of Cursil Compared with Vitamin B Complex on Chonicle Hepatitis Patient (Uji Klinis Efektivitas 'Cursil' Dibandingkan dengan Vitamin B Kompleks pada Penderita Hepatitis Kronis)

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Cursil is a phytopharmacal drug contains; 10 mg Curcuminoid from Curcuma domestica extraxtum sicc, 20 mg oleum xanthorrhizae from Curcuma xanthorrhiza extractum sicc. and 35 mg Silymarin from Silybium marianum extractum sicc., have been shown to exhibit significant anti-hepatotoxic actions and improved the liver function significant anti-hepatotoxic actions and improved the liver fuction tested by in vitro assay methods using Carbon Tetrachloride (CCI4) induced cytotoxicity in primary cultured rat hepatocytes. A randomized double-blind clinical study on the effect of Curcil in 60 patients of chronic hepatitis based on clinical criteria was investigated. There were 21 females, and 39 males. The age range from 38 to 60 years, with a mean of 50.1 years. For the purpose of this investigation, there were two preparations indentical in appearance, one being a Cursil as active phytopharmacal, and the other vitamin B complex as control drugs, in each capsul. All patients were given a uniform capsul three times daily for six weeks. The liver fuction test (SGOT less than SGPT less than Gamma GT and CHE) was examined before and every two weeks after treatment in all patients. Also the side effects, such as; gastrointestinal symptoms, allergic reaction, bleeding were observed. Among the liver fuction test, marked inprovement of SGOT, SGPT and CHE from the second week, and of Gamma GT in the fourth week of medication was significantly observed in the Cursil group. There were no side effects observed. There was significant group statistically. It is concluded that Cursil as a phytopharmacal have an anti-hepatotoxic effect and improving the liver function test inpatient with chronic hepatitis.

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Medika,22(6)1996:443-448

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: ., 1996

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hepatitis
vitamin b complex

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