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The Relation Between the Epression of Latent Membrane Protein-1 (LMP-1) and Diverse Expression of Cytokines, and Proteases in Nasopharyngeal Carcinoma its Realation With the Status of Node and Metastasis. Study on Molecular Bioloy and immunology Aspects

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n vitro studies reveal that LMP 1 induces the expression of many factors for invasion and metastasis. The aims of this study were to investigate role of LMP 1 expression on the status of N and M that take place either direcly of sequentially through its relation with the expression IL4, IL6, IL10, IFN-gamma, Granzyme B and with protease MMP2, MMP9, either in the serum or in the tumour tissue. Forty one 41 EBER-RIsh confirmed NPC cases with parallel serum were used for his study, immunohistochemistry was used to study the expression of proteins in the tissue. The serum level of proteins were determined with ELISA. Statistical analysis used Lisrel 8.50. No correlation between the expression of LMP 1 with the status of N and M of the tumour either directly or that sequentially took place through the expression of the cytokines and MMPs either in the tumour tissue or the serum level. The serum level of MMP9 was correlated with the serum level of IL6, the status of N, and the expression of IL10. Status N was correlated with serum level of MMP2. There is a process that sequentially took place through the increase of the cytokines, MMPs, either in the tumour tissue or serum level and N, M status. LM1 expression was not involved in the process.

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Detail Information

Series Title

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Call Number

Berkala Ilmu Kedokteran, 41(2): 55-62

Publisher

Yogyakarta : FK.Universittas Gadjah Mada., 2009

Collation

8p

Language

English

ISBN/ISSN

0126-1312

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

NEOPLASM NETASTASIS
CYTOKINES

Specific Detail Info

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