n vitro studies reveal that LMP 1 induces the expression of many factors for invasion and metastasis. The aims of this study were to investigate role of LMP 1 expression on the status of N and M that take place either direcly of sequentially through its relation with the expression IL4, IL6, IL10, IFN-gamma, Granzyme B and with protease MMP2, MMP9, either in the serum or in the tumour tissue. F…