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Gestational Transient Thyrotoxicosis

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Gestation transient thyrotoxicosis refers to nonautoimmune hyperthyroidism in pregnant women and it is associated with hyperemesis gravidarum. During pregnancy, there are some alterations in thyroid gland, such as elevation of thyroxine binding globulin, increased iodium clearance in kidneys, and stimulation of thyroid gland by human chorionic gonadotropin. Hitherto, the patholphysiology underlying the development of gestational transient thyrotoxicosis has not been fully recognized. Studies showed that human chorionic gonadotropin, an against of thyroid stimulatioting hormone, may stimulate thyroid stimulating hormone receptor, leading to increased thyroid hormone. Diagnosis of gestational transient thyrotoxicosis is established based on inexistence history of previous hyperthyroidism, elevation of thyroid hormone, absence of hyperthyroid abnormalities signs on physical examination (such as: enlargement of thyroid gland, exophthalmia), and the absent of positive thyroid autoantibody. Generally, gestational transient thyrotoxicosis does not require medication, unless if hyperemesis gravidarum is present, thus the patient has to be hospitalized to receive intravenous rehydration , electrolyte correction and antiemetic medication. On cases with worsened or protolonged symptoms, anti-thyroid agents such as short term propiltiourasil is needed.

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Detail Information

Series Title

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Call Number

Acta Medica Indonesiana, 41(2): 99-104

Publisher

Jakarta : RS. Cipto Mangunkusumo., 2009

Collation

6p.

Language

English

ISBN/ISSN

0125-9326

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

THYROTOXICOSIS

Specific Detail Info

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Statement of Responsibility

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