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Expression of NF-kB and COX-2 in Young Versus Older Patients with Sporadic Colorectal Cancer

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To distinguish the expression of NF-kB and COX-2 between young and older group of sporadic colorectetal cancer patients. This was a comparative study between sporadic CRC patients aged 40 years or younger and patients aged 60 years or more. Expression of NF-kB and COX-2 were assessed by immunohistochemical method using rabbit polyclonal antibodies against human p65 NF-kB and COX-2 proteins. There were 98 cases of sporadic colorectal cancers between 1999 and 2007 obtained from the Departemen of Anatomical Pathology. Faculty of Medicine University of Indonesia, Jakarta and Departement of Anatomical Pathology, Faculty of Medicine Padjajaran University, Bandung. There were 60 patients aged 60 years or more located in the dstal colon. Positive expression of NF-kB was found in 72 (73.5%) cases, whereas COX-2 expression was found in 48 (49.0%) cases. No significant difference of NF-kB and COX-2 expression between young and older patients. The expression of nuclear factor kB (NF-kB) in Indonesian patients with sporadic colorectal cancer was high. However, cyclooxygenase-2 (COX-2) was only expressed in half of patients. There was no significant difference of NF-kB and COX2 expressions between patients aged 40 years or less and patients aged 60 years or more. Further studies are needed to elaborate the role of inflammation in sporadic colorectal carcinogenesis.

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Series Title

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Call Number

Acta Medica Indonesiana, 41(2): 70-74

Publisher

Jakarta : RS. Cipto Mangunkusumo., 2009

Collation

5p.

Language

English

ISBN/ISSN

0125-9326

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Edition

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Subject(s)

colorectal neoplasms
inflammation

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