Efficacy of Chloroquine, Chloroquine Plus Sulphadoxine-Pyrimethamine, and Amodiaquine for treatment of Vivax Malaria in Bangka Island, Indonesia: a Randomized Trial | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Efficacy of Chloroquine, Chloroquine Plus Sulphadoxine-Pyrimethamine, and Amodiaquine for treatment of Vivax Malaria in Bangka Island, Indonesia: a Randomized Trial

Emiliana Tjitra - Personal Name; Nurhayati - Personal Name; Ferdinand Laihad - Personal Name; Boy Yandri - Personal Name; Boy Tandri - Personal Name; Wmi Yuwarni - Personal Name; Syahrial Harum - Personal Name; Sri Suprianto - Personal Name; Budi Prasetyorini - Personal Name; Maladi - Personal Name; Pasca Ringwald - Personal Name;

Plasmodium vivax malaria resistant to chloroquinenis alarming in Indonesia and has been also reported in other countries. An alternative drug is needed. The study was a prospective evaluation and a comparative study of the therapeutic efficacy of choloquine 25 mg base/kg bw for 3 days (CQ3 plus sulfadoxine-pyrimethamine based on pyrimethamine of 1.23 mg/kg bw single dose (SPI) [CQ3=SPI, n=84] and amodiaquine 25 mg base/kg bw for 3 days (AQ3, n=83) in symptomatic vivax malaria patients in children and adults. The new version of 2001 WHO test system was used in this study. PCR for genotyping was also done to validate and confirmthe treatment outcomes. The therapeutic efficacy of CQ3+CQ3+SPI and AQ3 on day 14 were very high 4%, 97.4% and 98.8% and dropped on day 28 (81.7% and 96.2% by evaluable analysis: 78.9%. 82.0% and 92.5% after confirmation with PCR: and 74.7%, 78.0% and 90.2% by intention to treat analysis). Most of the ACPR cases (>96% showed hematological recovery. Gametocyte carriages were documented on day 7(2,9%, 1.3% and 1.2%), day 14 (4.3% and 1.2%) and day 28 (6.6%, 4.2% and none) in CQ3, CQ3+SPI and AQ3 group. Of these 3 regimens, AQ3 showed a better therapeutic afficacy than CQ3 and combined CQ3+SPI by day 28. Introducing primaquine at the beginning of treatment day or giving a radical treatment in vivax malaria may improve the cure rate.

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Location name is not set Medical Joural of Indonesia, 17(2):96-106

A00002207

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Series Title: -
Call Number: Medical Joural of Indonesia, 17(2):96-106
Publisher: Jakarta : Fk. Universitas Indonesia., 2008
Collation: 7p.
Language: English
ISBN/ISSN: 0853-1773
Classification: -
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): malaria
chloroquine
SULFADOXINE
Specific Detail Info: -
Statement of Responsibility: -

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