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ABSTRACT: Anemia is prevalent in chronic kidney disease (CKD) patients and associated with increased morbidity and mortality. Current management of anemia in CKD resolves around iron supplementation, erythropoiesis-stimulating agents (ESA), and red cell transfusion. Hepcidin is a peptide produced in liver and is a key regulator of systemic iron homeostasis to prevent iron overload by iron se…
ABSTRACT: Gouty nephropathy or chronic uric acid nephropathy is a situation where uric acid or crystal is deposited on parenchyma and lumen of kidney tubule independently, causing chronic inflammatory response via direct injury, similar to formation of microtophus in other organs, causing interstitial fibrosis and finally kidney failure. Deposition of uric acid or crystal formed because of h…
ABSTRACT Plasmodium knowlesi has been recognized since 1932 as a parasite that causes malaria in monkey. There have been numerous reports of naturally acquired infections of Plasmodium knowlesi in human in Southeast Asia. Natural infections in human frequently diagnosed as Plasmodium malariae because they are microscopically similar. The most characteristic symptom is fever occuring every 24…
ABSTRACT: Pericarditis is an inflammation of parietal pericard, visceral pericard or both, caused by infection, systemic autoim mune disease, post-myocardial infarction syndrome, metabolic abnormalities, pregnancy, traumatic, neoplastic, iatrogenic, or drugs.1,2The prevalence is 2 to 3.5% of all large pericardial effusion. The incidence of cardiac tamponade in the United States is 2 per 10,0…
ABSTRACT: Peripartum cardiomyopathy is a form of dilated cardiomyopathy that usually happens from the last month of pregnancy until 5 months after delivery. Patients with peripartum dilated cardiomyopathy will experience symptoms and signs of chronic heart failure such as decreased excersise tolerance, tachypnea, palpitation, tachycardia, narrow pulse pressure and fatigue. Peripartum cardiom…
ABSTRACT: Lumbrokinase is a group of serine protease enzymes that is extracted from alimentary tract of the earthworm. Lumbrokinase has been shpwn to have fibrinolytic and antithrombotic activities due to its ability to hydrolyze fibrin and fibrinogen, and to activate plasminogen to become plasmin. It is different from other fibrinolytic agents; lumbrokinase is an oral fibrinolytic easily ab…
ABSTRACT: Atrial fibrillation (AF) is a supraventricular tachyarrhythmia characterised by uncoordinated atrial activation. The incidence of AF is increasing especially with increasing life expectancy. Despite new insights in the pathophysiology and development of novel ablative technique and anti arrhythmic drugs, the management of this chronic rhythm disturbance remains problematic. There a…
ABSTRACT: Tetralogy of fallot (ToF) is a complex of anatomic abnormalities arising from maldevelopment of the right ventricular infundibulum. ToF occurs in approximately 1 in 3,600 live births or 3.5% of infants born with congenital heart disease. It is the most common type of cyanotic congenital heart disease, accounting for 10% of all cases. With early diagnosis and appropriate treatment, …
ABSTRACT: Current recommendations on the prevention of coronary heart disease in clinical practice stress the need to base intervention on an assessment of the individual's total burden of risk rather than on the level of any particular risk factor. This is because most people have several risk factors which interact to produce their total risk. There is a need for clinicians to be able to e…
ABSTRACT: Seborrheic keratosis is the most common benign epidermal tumor. Destruction with cryotherapy, electrodesiccation, curettage, or laser ablation (carbon dioxide or erbium:YAG) are effective. We performed a split-face comparison of carbon dioxide laser versus electrodesiccation for the treatment of facial seborrheic keratoses. This is a case report of a 61-year-old woman presented wit…