ABSTRACT: Lumbrokinase is a group of serine protease enzymes that is extracted from alimentary tract of the earthworm. Lumbrokinase has been shpwn to have fibrinolytic and antithrombotic activities due to its ability to hydrolyze fibrin and fibrinogen, and to activate plasminogen to become plasmin. It is different from other fibrinolytic agents; lumbrokinase is an oral fibrinolytic easily ab…