Abstract. Systemic sclerosis (scleroderma) is a connective tissue disease of the unknown causes that characterized by fibrosis of skin and visceral organs as well as micro vascular abnormalities. The prevalency of the patients is relatively low with 50-300 cases per 1 million of the population and the incidence of 2.3 to 22.8 cases per I million population per year; however, the risk on women i…