ABSTRACT Immune responses against malaria can lead to immunopathologic condition. Echinacea purpurea is a potent agent to enhance immunity. This study aims to reveal the effect of Echinacea in the treatment of malaria in vivo. This study is pre and postest control group design using 24 mice mus musculus strain DDI male, aged 5 weeks, weight 20-25 gram divided into 5 groups: K- (no treatment)…