Background: Nitric oxide (NO) has a potential rule in pathogenesis of systemic hypotension in septic shock. Endotoxin has been shown to increase the activity of the iNOS enzyme and NO release. Proinflamatory cytokines are inflammatory mediators which implicated in the induction and anion of iNaS and NO release also. Ketamine is anesthetic agent and commonly used for patients. This agent suppres…