The study of the water fraction of Piper bade L. leave ethanol extract activity to decrease appetite and body weight in male Wistar rats have been conducted. In this study, 25 males Wistar rats (Rattus norvegicus) were divided into 5 groups (negative control group - K(-); 3 test groups- Fl, F2, F3, and positive control group- P). The K(-) was treated 3% of PGA; F1, F2, F3 were treated by water …