This research is aimed at testing of Tween-80 and DMSO in of Sodium Diciphenac, to increase the penetration of the active ingeredient. The lest of active ingredent was determined by Franz cell diffusion of vertical type by using rat skin and NaCI 0,9% as the recelving solution. The content of penetraining active ingredient was determined by UV-Visible spectrophotometry. The rresults showed the …