Diabetic retinopathy (DR) is a visual disorder caused by the diabetic microvascular complications. Genetic polymorphism in the vascular endothelial growth factor (VEGF) gene plays an important role in the susceptibility of DR. The aim of this study was to evaluate the association of the polymorphism of VEGF gene insetion/deletion (I/D) -2549 with DR in Javanese type 2 diabetes mellitus (DM)…
Oxidative stress has been implicated in pathogenesis and progression of many degenerative disorders including naturally occurring and chemically-induced diabetes mellitus. In addition to the increased production of free radicals, antioxidant defense systems are disturbed in diabetes mellitus. As a result, oxidative stress may cause oxidative damage of cellular, including ß-cells of pancreas. T…