The bis-spiroepoxide dithiane dioxide has been attempted to be synthesised as its role as an intermediate in the synthesis of diaminopimelic acid (DAP). The first method was carried out by reacting the 3-dithiane-2- diethylphosphonate 4 with an aqueous solution of the commercially available glutaraldehide resulting the bis-ketene dithiane dioxide 5. The second alternative method was involving t…
LR-2 is a compound analog of monastrol, an anticancer agent, which has been succesfully synthesised through the application of Biginelli reaction and one of LR compound series that synthesised in faculty of Farmacy, Universitas Gadjah Mada. This research was aimed to synthesized the LR-2 compound and to investigate the cytotoxicity of LR-2 on breast cncer cell line. The reaction was carried out…
Sepsis is a systemic response to infection especially in pneumonia case. Sepsis can cause complications such as disseminated intravascular coagulation (DIC) which can be divided into compensated and decompensated DIC. The purpose of this study was to assess whether the value of prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, and D-dimer levels can be used as pre…
Tetrahydropentagamavunon-O (THPGV-O) is assumed to be main metabolite product of biotransformation process of PGV-O. THPGV-O was synthesized by converting PGV-O to the compound by hydrogenation with PdjC as a catalyst. PGV-O potently inhibited the histamine release from ~at mast cells in vitro and in vivo, however, ironically only traces amount of compound was found in the blood. THPGV-O is ass…
Asthma is a chronic inflammatory airway disease involving reversible airway constriction and airway hyperresponsiveness (AHR) to allergens, airway edema, and increased mucus secretion turner cells. To date, exploration of antiasthmatic drug is still being studied both from natural products or sinthetic processes. One of the sinthetic compound is pentagamavunon-O (PGV-O) which possesses anti-inf…
Commersial Fibrin Glue (CFG) as a biomaterial adhesive from fresh frozen plasma donor and bovine has been tsted having various superiorities compared to suturing in bulbar conjunctiva grafting of ptergium surgery. Due to CFG has not been available in Indonesia led the author to make an Autologous Fibrin Glue (AFG) directly from patient’s own blood. The study aim was to investigate the effecti…