In the late 1992, a large epidemic of cholera-like disease due to a novel strain belongs to the non-01 serogroup of Vibrio cholerae broke out in the Southern Indian port city of Madras. The disease affected thousands of individuals, mainly adults, and caused many deaths in the sub continent. The epidemic strain was not related to the 137 known non-01 serogroups; therefore, a new serogroup, 0139…