Curcumin in Curcuma xanthoryza could inhibit cytochrom P-450 CYP1 A 1, CYP1 A2 and CYP4A. It has been used as herbal remedy safely as anti inflammation. The aim of the research at find the effects of the herbal on AUC and Cmax ibuprofen ofmale rats. Male rats ofWistar strain with bodyweight between 180-200g was used as test animals. Test animals in the control group was given ibuprofen suspensi…