We report one female newborn baby suffered from moderate asphyxia meconium aspiration syndrome, and Hirschsprung disease. The patient admitted in Neonatal intensive Care Unit (NICU) and ventilated with Pressure Controlled Mandatory Ventilation(PCMV) mode ventilator. Patient suffered from penumodiastinum and therefore mediastinotomy was performed. Sepsis and Necrotizing Enterocolitas (NEC) made …