Therapeutic index, a drug safety parameter, is comparation between the dose at which 50% animals are dead (LD50) and the dose at which 50% animals exhibit the specified effect (ED50). Inflammation was a basic process in various diseases and Dewa leaf {Gynura pseudochina (Lour.) DC} was one of the herbal plants which has been proved as an anti-inflammatory. This study was conducted in order to k…