Gonadotro inhibits GnRH-stimulated gonadotropin secretion in the Sheep by action on the piltultary gonadotropes. Estradiol -17β (E₂) also at the level of the pitultary gonadotrope to exert negative and positive feedback effects on gonadotropin secretion. The positive effect facillitates the estrogen-induced surge in gonadotropin releasing hormone (GnRH) and LH. This study was undertakento de…