UVB radiation may act as immunosuppressive agent through angerhans cels (LCS) depletion correlated with cyclobuthane pyrimidine dimer (CPD), as the most mutagenic photoproducts. Other studies showed that olive oil can prevent various human cancers which are defect of immune-surveillance. The effect of olive in the UVB-induced LCs depletion is still unclear. To discover the topical effect of ext…