ABSTRACT Antidiabetic use on renal disturbance patients need to applicate principal of clinical pharmacokinetics. Decreasing renal function could distrub excretion drug and increase accumulation drug within the plasma, therefore, toxic effect will be produced and it need to adjust dose. This research aimed at studying of clinical pharmacokinetic of oral antidiabetics on diabetes mellitus (DM) …
Sodiumascobyl phosphate is a hydrophilic derivate of asorbic acid, which has chemically more stable. As an antioxidant it can scavengeand destory aggressive oxidizing agents and free radicals that are improtantly involved in the skin aging process. Microemulsion is carrier systems for topical delivery of sodium ascophate. An experiment has been conducted with virgin coconut oil (VCO) as an oil …