Abstract: Synthesis of I ,S-bis(3' -etoxy-4' -hydroxyphenyl)-I ,4-pentadiene-3-on (EHP) by aldol condensation method from ethyl vanilin and acetone, using hydrochloride acid as a catalyst, has been conducted. Identification of the EHP compound was done through interpretation of UV- Vis, FT-IR, GC-MS and NMR data. The antioxidant activity of EHP (ICso 8.66 ug/ml.) is higher than curcumin (ICso 1…