Transforming Growth Factor-Beta 1 (TGF-β1) menjadi perantara fibrosis interstisial, atrofi tubular, dan kerusakan gromelurus ginjal. Proteinuria menunjukkan prognosis yang buruk pada sindroma nefrotik. Terdapat kecenderungan persisten proteinuria pada sindroma nefrotik resisten steroid. Tujuan penelitian ini untuk membuktikan hubungan kadar Transforming Growth Factor-Beta 1 (TGF-Î…
Resitance to steroid therapy is a poor prognosis sign for nephrotc syndrome, but the mechanism is still unclear. NF-kB has been reported to affect the glucocortiroid at the T cell through the transrepression in the glucocorticoid receptor. Until know, this study was still limated. The aim of this study was to show the difference expression and activation of NF-kB p65 subunit between childhood S…
Glucocorticoid receptors (GR) have an important role in the resistance of steroid of steroid therapy. Previous studies showed significant difference activation and expression of GR between Steroid Resistant Naphrotic Syndrome (SRNS) and Steroid Sensitive Nephrotic Syndrome (SSNS), however the other studies showwed contrastive result. Previous studies also revealed Hsp-90 had an important role i…
Cerebral and lung during malaria infection is believed to be caused by free radicals activities that are produced during immunology process. The free radicals reacts with lipid component of cellular membrane which generates malondialdehyde (MDA) at its end-product. The aim of the research was to determine whether combination of artemisinin and NAC was more effective in decreaseing cerebral and …