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Prospect of Nucleic-Acid Based Immune System-RNAi as Potent Antiviral Agents
The invention of RNA interference (RNAi) machinery as a gene expression silencer may revoulutionize the approach to infectious diseases treatment. A long-standing problem such as viral resistance to chemotherapeutic agents due to the high rate of mutation seen in HIV-1 may soon be overcome by the application of RNAi as a nucleic-acid based immune system. The RNAi uses dsRNAs converted into mult…
- Edition
- -
- ISBN/ISSN
- 0125-913X
- Collation
- 4p.
- Series Title
- -
- Call Number
- Cermin Dunia Kedokteran,36((5):340-343
The Therapeutic Potential of RNA Interference in Controlling HIV-I Replication
Human immunodeficiency virus type I (HIV-1) has long been a major problem to handle. Its existence is incurable (yet) and has reached pandemic proportions despite strictly-controlled epidemiological surveillance. The current treatment regimen involves the use of multiple antiretroviral agents (known as HAART) is very complex and may harm patients through its serious risk of toxicities. Moreove…
- Edition
- -
- ISBN/ISSN
- 0125-9326
- Collation
- 7p.
- Series Title
- -
- Call Number
- Acta Medica Indonesiana, 41(4): 215-221
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