Physiological basis for the actions of plantderived cannabinoids has been explained has been explained by the discovery of two cannabunoid receptors and the their endogenous ligands, the endocannabinoids The substances include anandamide, 2-arachidonoyl glycerol (2-AG), noladin ether, NADA and virodhamine. The encocannabinoid receptor (ECBR) system ilfluences energy balance and food intake at f…
Nitric oxide (NO) was once regarded as a noxious environmental pollutant, when in the 1980s several lines of research showed that NO is essential of the human body. NO is a short-lived gas that is produced locally from L-arginine by the enzyme NO-synthase NOS). NOS is found in preganglionic and postganglionic autonomic neurons, as well as in vascular endothelial cells. Inside the VSMC (vascula…