Burden disease of hypertension globally was 4,5 % (64 million patients with life disability-adjusted / DALYS). Prevalence of Hypertension in Indonesia was about 31,7% with age 18 years above. RSUD Margono Soekarjo as one of the biggest hospitals in Central Java specified therapy standard for hypertension by using drug of amlodipine or ramipril. The aim of this research was to determine comparis…