Gamavuton-0 (GVT-0), also nemed as 1,5-bis(4’hydroxy—3-methoxyphenyl)-1-4-pentadiene-3 0ne is a 1,5-diphenyl-1-4-pentadiene-3 one analog of curcumin by modifying the center site of curcumin leading to 1,4-pentadiene-3-ones to maintain the hydroxy moiety at aromatic rings which are responsible for its biological activities. Curcumin has been reported to have potrnt anticarcinogenic effects. …
PGV-1 or 2,5-bis(4’-hydroxy-3,5’-dimethylbenzylidene) cyclopentanone and RGV-2 or 2,5-bis(4’-hydroxy-3’-5’-diethybenzylidene)cyclopentanone are tro benzylidene cyclopentanone analogues of curcumin. In or study, we ivestiggeted the effects of these compounds on the β-hexoaminidase enzyme relese from mast cell culture (RBL-2H3 cell line,). Thapsigargin and lonomycin were used as intrac…
Hypertension is a disease which need a complex therapy and high cost of drugs. This fact urge exploration of new antihypertensive drug. The aim of the research was to asses to look at the activity of curcumin and its derivatives bisdemethoxy curcumin and bis (demethoxydehydroxy) curcumin on the contraction of isolated organ smooth muscle induced by an ά1 – on the adrenergic receptor agonist …