Inhibitor Effect of THPGV-0 on the Histamine Release From Antigen-Induced RBL…

Tetrahydropentagamavunon-O (THPGV-O) is assumed to be main metabolite product of biotransformation process of PGV-O. THPGV-O was synthesized by converting PGV-O to the compound by hydrogenation with PdjC as a catalyst. PGV-O potently inhibited the histamine release from ~at mast cells in vitro and in vivo, however, ironically only traces amount of compound was found in the blood. THPGV-O is ass…

Effects of Pentagamavunon -0 on Histaminemediated Hyperresponsive Airway in A…

Asthma is a chronic inflammatory airway disease involving reversible airway constriction and airway hyperresponsiveness (AHR) to allergens, airway edema, and increased mucus secretion turner cells. To date, exploration of antiasthmatic drug is still being studied both from natural products or sinthetic processes. One of the sinthetic compound is pentagamavunon-O (PGV-O) which possesses anti-inf…

The Influence of the Aging through H1 Histamin Receptor Change in Marmot Ileu…

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Majalah Farmakologi dan Terapi Indonesia,12(1)1996