Plasmodium vivax malaria resistant to chloroquinenis alarming in Indonesia and has been also reported in other countries. An alternative drug is needed. The study was a prospective evaluation and a comparative study of the therapeutic efficacy of choloquine 25 mg base/kg bw for 3 days (CQ3 plus sulfadoxine-pyrimethamine based on pyrimethamine of 1.23 mg/kg bw single dose (SPI) [CQ3=SPI, n=84] a…
At present quinine is the antimalaria drug of choice in the treatment of chloroquine or multidrug resistant malaria and severe or complicated malaria. Artemisinine, a new antimalarial has been reported to be highly effective and of low toxicity. Therefore, artemisinine derivates (artesunate and artemether) need to be evaluated to have an alternative drug to be used in Indonesia. The study has b…
Resistance to chloroquine by Plasmodium falciparum in the Oksibil region of Irian Jaya was evaluated by in vivo testing in July 1994 among 44 patients. Study subjects ranged in age from 5 to 42 years. At day 7 of the test 10 subjects (23 percent) had persistent or recurrent asexual parasitemias. Among these infections, 8 were classified RII and 2 RIII levels of resistance on the basis of the po…
Resistance to chloroquine by Plasmodium falciparum in the Oksibil region of Irian Jaya was evaluated by in vivo testing in July 1994 among 44 patients. Study subjects ranged in age from 5 to 42 years. At day 7 of the test 10 subjects (23 percent) had persistent or recurrent asexual parasitemias. Among these infections, 8 were classified RII and 2 RIII levels of resistance on the basis of the po…
A study on choroquine effect to the lymphocyte proliferation of BALB/c mice spleen, infected by Lysteria monocytogenes was carried out. Chloroquine, used for curing malaria and rheumatoid arthritis, is known suppressed the imune response. In this study, 70 BALB/c male mice were divided in 3 groups. The first and the second groups consist of 3 subgroups, which each subgroup consisted of 10 mice.…