Hypertension is a disease which need a complex therapy and high cost of drugs. This fact urge exploration of new antihypertensive drug. The aim of the research was to asses to look at the activity of curcumin and its derivatives bisdemethoxy curcumin and bis (demethoxydehydroxy) curcumin on the contraction of isolated organ smooth muscle induced by an ά1 – on the adrenergic receptor agonist …