Multiple mini punch grafts is the placing of mini size of full thickness skins on to ulcer bedo They consist of epidermal and dermal component composed with hair follicles and other skin appendices where epidermal stem cells are located. The epidermal stem cells are the best source of epidermal cells in reconstruction of skin equivalent that is usually used for replacing classic split thickness…
ABSTRACT One side effect of non-steroidal anti-inflammatory drugs is gastric mucosal irritation, possibly causing gastric ulcers. The aim of this study was to evaluate the protective effect of cincau leaves ( Cyclea barbata Miers) on aspirin-induced gastric ulcer in Balb/c mice. Twenty five Balb/c mice (20-30 g, 2-3 months old)were randomly divided into 5 groups. Group I-III were given cincau…
Fllngsi utama n//lieus at/a/ab fIIcncipftlleLln kestabilan, me'!iaga PH netral dan sebagai sawar terhadap pepsin, sebingga mclindungi tIIukosa dari clI,{jlJl proteo/itik pencernaan. Sedangkan flmgsi taama sekresi bikarbonat adalab menetraiean asas: yang berdifilSi ke datam IIl11kllS dan IIItmelibam pH yang mendeeati netral-netrai antara nlllkus - 11Iukosa. Pada kondisi fisiolog;s fllngsi sasuar…
Ulcer healing process is an intricate and active process including reconstruction process of mucosa through formation of granulation tissue. Granulation tissue formation takes place by means of formation of ulcer base, formation of blood vessel (angiogenesis) and re-establishment of glandular architecture. The process of granulation tissue formation on the ulcer base takes place 48-72 hours aft…
Gastrointestinal toxicity due to non-steroid anti-inflamatory drugs can be inhibited by the compounds that have antioxidant activity. Quercetin is a flavonoid that has antioxidant activity and protection effect against ulcer. Chlorination of quercetin anhanced the antioxidant. This study aims to obatin the chlorinated derivative of quercetin and examine the protection effect against acetosal-i…
Peptic mucus synthesize especially prostaglandine E2 and I2. Prostaglandine E2 and I2 can impede acid secete and stimulate mucus and bicarbonate secretion. Misoprostol, a synthetic methyl ester analogue of prostaglandin is both a powerful inhibitor of gastric secretion and is able to protect the gastroduodenal mucosa from damage. Misoprostol and other prostaglandine derivatives can be alternati…
Quercetin is a flavonoid having anti-inflammatory activity by cyclooxygenase -2 inhibition. In addition quercetin has a cytoprotective activity against gastric ulcer due to its antioxidative activity. The objevtive of this research was to obtain quercetin derivative through selective acetylation and to find out the anti-inflammatory activity and gastric ulcer side effect of the synthesis produc…