Alpha tocopherol, also has a non anti-oxidant activity that corrrelates with inhibition of PKC-alpha isozyme activity. Several studies confirmed its role in ihhibition of vascular smooth umscle proliferation. Inhibition of stromal cell proliferation is an alternative method of prevention of BPH. The aim of this in vitro study is to confirm that alphatocopherol, by its ability to inhibit PKC-alp…
To prove that glucose treatment in human prostatic stromal cells (GPSC) culture wound increase PKC alpha isozyme activity. Primary cuktures of HPSC were obtained from patients with blader outlet obstruction caused by benign prostatic enlargement. The effects various contrations of glucose (5,10.15.20.30.35 micro-Mol) on PKC-alpha isozyme activity were examined quantitatively by spectropotometry…