ABSTRACT One side effect of non-steroidal anti-inflammatory drugs is gastric mucosal irritation, possibly causing gastric ulcers. The aim of this study was to evaluate the protective effect of cincau leaves ( Cyclea barbata Miers) on aspirin-induced gastric ulcer in Balb/c mice. Twenty five Balb/c mice (20-30 g, 2-3 months old)were randomly divided into 5 groups. Group I-III were given cincau…
Gastrointestinal toxicity due to non-steroid anti-inflamatory drugs can be inhibited by the compounds that have antioxidant activity. Quercetin is a flavonoid that has antioxidant activity and protection effect against ulcer. Chlorination of quercetin anhanced the antioxidant. This study aims to obatin the chlorinated derivative of quercetin and examine the protection effect against acetosal-i…
Quercetin is a flavonoid having anti-inflammatory activity by cyclooxygenase -2 inhibition. In addition quercetin has a cytoprotective activity against gastric ulcer due to its antioxidative activity. The objevtive of this research was to obtain quercetin derivative through selective acetylation and to find out the anti-inflammatory activity and gastric ulcer side effect of the synthesis produc…
Eurycoma lonifolia (pasak Bumi) are widely found in East Kalimantan. Etnobotanically, the roots of this plant were used to decrease gastric pain and anti ulcers, but scientific evidences have not been available yet. The objective of this research was to test the anti-ulcer effect of Eurycoma longifolia against gastric ulcer in rats. Water extract of Eurycoma longifolia’s given to the rats bef…