Non Steroid Anti-Inflammatory (NSAID) is one type of Anti-Inflammatory drug that is used to treat pain in patients of osteoarthritis (OA) and rheumatoid arthritis (RA). The use of NSAIDs can cause gastrointestinal side effects. To prevent the side effects, NSAIDs are prescribed in combination with gastroprotective agent (GPA). The aim of the study is to determine the factors considered in the G…
ABSTRACT One side effect of non-steroidal anti-inflammatory drugs is gastric mucosal irritation, possibly causing gastric ulcers. The aim of this study was to evaluate the protective effect of cincau leaves ( Cyclea barbata Miers) on aspirin-induced gastric ulcer in Balb/c mice. Twenty five Balb/c mice (20-30 g, 2-3 months old)were randomly divided into 5 groups. Group I-III were given cincau…
Steroid resistant nephrotic syndrome (SRNS) due to nephrotic syndrome type 2 (NPHS2) gene mutation has more severe clinical manifestation than those without mutation. This study was designed to find NPHS2 gene mutation in 412C→T and 419delG in Indonesian SRNS and to see differences in clinical manifestation. The observational cross sectional study was performed on 88 SRNS. Subjects were taken…
Relapse were common in children with steroid-sensitive nephrotic syndrome (SSNS). Risks of relapse were age at onset, atopic history, acute viral respiratory tract infection (ARI), and genetic. Releasing of interleukin is associated with relapse mechanism in nephrotic syndrome and may be precipitated by high humidity and low temperature as in rainy season. The aim of this study was to determine…
The goals of this miniview are: Firstly, to know that the cross-talk may be defined as a functional interaction between two (or more) signaling pathways. And also cross-talk may involve different steps of the pathways. Some signaling molecules are able to bind to and activate different nuclear receptors. In addition, some ligands may be be agonist of a given nuclear receptor and antagonist or i…
The goals of this miniview are: Firstly, to know that the cross-talk may be defined as a functional interaction between two (or more) signaling pathways. And also cross-talk may involve different steps of the pathways. Some signaling molecules are able to bind to and activate different nuclear receptors. In addition, some ligands may be be agonist of a given nuclear receptor and antagonist or i…