Objective: To know the relationship between p53 expression and prostate specific antigen (PSA) serum level in prostate cancer patients. Material & method: Specimens were studied from patients with pathological diagnosis of prostate cancer in Sardjito Hospital Yogyakarta during 2007 to 2008. The p53 expression was measured by immunohistochemical staining. The stains were done in Department ofAna…
Objective: To determine the association between p53 expression and the level of organ confinement in patient with prostate cancer in Sardjito Hospital, Yogyakarta. Material & method: Prostate specimens were obtained from patients with clinical stage T1-T2 prostatic adenocarcinoma in Sardjito Hospital between January 2007 and December 2008. Samples were processed and immunohistochemically staine…
This research problem is the high incidence of patients with benign prostetic hyperplasia with a catheter placed through an out patient basis. The study is a descriptive study with the aim of knoWtng the family knowledge about catheter care at home in patients with benign prostatie hyperplasia who underwent outpatient in Poly Urology Sidoarjo Hospital. As the population is all the families of p…
Objective: To find out the role of inflammations in BPH progression represented by prostate enlargement compared between age group.Material & method: Tissue samples of BPH were collected from biopsy, transurethral resection or open surgery. Clinical information such as age of the patient, prostate volume, prostate specific antigen (PSA) blood concentration and history of retention before proced…
Objective: To investigate the efficacy of intermittent doxazosin therapy on LUTS associated BPH.Material & Method: This study was performed between January to April 2010 enrolling 20 patients with LUTS associated BPH. Study subjects were randomly allocated to 2 therapeutic groups. The first group was assigned daily doxazosin therapy (11 patients), while the second group was assigned intermitten…
Objective: To study the relationship between obesity, prostate specific antigen (PSA) level, and prostate volume in patients with benign prostate hyperplasia (BPH) without urinary retention.Material & Method: Twenty two BPH patients without urinary retention was enrolled in this study. Patients were classified into 2 groups based on body mass index (BMI). The first group consisted of 11 patient…
The role of inflammation in prostate diseases is suggested by the presence of inflammatory cells within the Benign Prostatic Hyperplasia (BPH) and Prostate Cancer (PC). Inflammation suggests influence a balance between prostate cell growth and apoptosis by increasing microenvironment around prostate factors such as cytokines, COX-2 and oxidative stress. These factors stimulate proliferation and…
The increasing population of elderly men means there is also an increase in those suffering from late-onset hypogonadism and testosterone deficiency, with all its attending consequences such as reduced libido, erectile dysfunction, metabolic disturbances, cardiovascular disease, decreased bone density and reduced quality of life. The use of testosterone replacement therapy may benefit such pati…
Aim To construct tissue microarrays (TMAs) that consisted of prostate tumours from the transgenic adenocarcinoma of mouse prostate (TRAMP) mice and non-transgenic murine prostates and to assess androgen receptor (AR) levels during progression of prostate cancer in TRAMP mice by immunohistochemistry. Methods Haematoxylin and eosin (H&E) sections from the ventral and dorso-lateral prostate lobes…