Atenolol has a low oral bioavailability and a short elimination half-life. Therefore, alternative delivery system isimportant. Transdermal iotophoresis i.e. a systemic drug delivery via the skin, implementing a low intensity of electrical current, is one attractive candidate. This study evaluated feasibility of atenolol transdermal transport when lontophoresis was applied after enhancer pretrea…
Propranolol has an intensive first pass metabolism. Resulted in a low oral biovailability. One alternative first pass metabolism, resulted in a low oral biovailability. One alternative to circumvent such problem is the delivery by transdermal route. The objective of this study was to evaluate the effect of oleic and 10% (in propylene glycol 20%) as enhancer, with and without lotophoresis, on tr…