Helminth infection and allergy are associated with elevated levels of IgE, tissue eosinophilia, mastocytosis, and CD4+T cells that initiating by secreting the Th2 cytokines IL-4, IL-5, and IL- 13. However, interaction between the factors was still unclear. This article try to review some articles that related with helminth infection, allergy, and immune system to figured out holistically to exp…