Background: Exercise increases the need for oxygen to generateATP through oxidative phosphorylation. If the high energy demand during exercise is not balanced by sufficient oxygen supply, hypoxia occurs in skeletal muscle tissue leading to upregulation ofhypoxia inducible factor-1α (RIF-1α). The activity of RIF-1α increases the expression ofvarious genes in order to reduce the metabolic depe…
Vascular Endothelial Growth Factor (VEGF) adalah protein angiogenik yang dihasilkan oleh sel tumor, dibantu sel endotel dalam peranannya bagi pertumbuhan tumor. VEGF berkaitan dengan vascular endothelial growth factor receptor (VEGF) dipicu keadaan hipoksia dan onkogen ras mutan. VEGF tidak bekerja pada sel endotel istirahat dan pembuluh darah dewsa. Ada 6 betuk isoform VEGF yaitu VEGF-A,B,C,D,…
Aim Circulating endothelial progenitor cells (EPCs) are reduced in number and function in patients at risk for cardiovascular diseases. On the other hand, hypertension is related with excess angiotensin II which would lead to oxidative stress. In this study,we investigated the correlation between F2-Isoprostane (as marker of oxidative stress) with Stromal Cell-Derived Factor-1 (SDF-1) and CD34 …
Objective: To analyze the expression ofMHC class Ib Qa-2 pro¬tein (homologue to HLA-G in human), Hsp-70, and VCAM-I in tro¬phoblast cells of preeclampsia and control using endothelial dys¬function model on Mus Musculus. Method: Design of study is experimental study. Pregnant mice was treated with anti-Qa-Z. Hsp-70 and VCAM-l expressions of trophoblast cells was assessed on week I, Il, and I…
Aim Normotensive overweight adolescents may have endothelial dysfunction which is not clinically detected in a routine clinical examination. The purpose of this study was to detect endothelial dysfunction in normotensive overweight using Dundee step test. Methods Sixty two subjects consist of 31 normoweight and 31 overweight group participated in this study. Blood pressure measurement was take…