Background: Cobalt chloride can be used as an agent to stabilize hypoxia inducible factor-1α (HIF-1α) and to imitate hypoxia without low levels of oxygen inside the body. We intended to Investigate if there was any regulation of renin expression by HIF -1α. Therefore, we conducted several studies to elarify this possibility starting with the induction of hypoxic mimicry in rats by intra-per…