The Objective of this work was to formulate and evaluate captopril gel to assess its suitability for transdermal delivery by passive and iontophoresis. A polymer gel was prepared using hydroxypropyl methyl cellulose and in vitro skin permeability was assessed in full thickness skin of rabbits and pigs. For in vivo studies New Zealand rabbits were used. In vitro passive permeation was carried ou…
Captopril is a selective- Inhibitor of angiotensin-convertinq enzyme (ACE) and is formulaned by, several pharmaceuical companies: irr Lndonesia. This stwdy was corrducted to compare tlhe bioavailability of captopril' tablet with reference preducts in healthy volunteers. The relative bioavailability of captopril was deterrnined in single dase, randomized, crcssover, and two-phase studies. The re…