Parasite resistance to antimalarial drugs is an obstacle to malaria elimination. In Plasmodium vivax, up to now, a marker to distinguish between resistant and susceptible is no available yet. Identify Single Nucleotide Polymorphisms (SNP) in P. vivax for multidrug resistance (pvmdr1)is potential approach due to pvmdr1 gene is orthologous to the pfmdr1 of P.falciparum, have been related to multi…
A practical and simple Artemisinin based combination therapy (ACT) with good compliance in adult patients for all malaria species has been shown in the first article: “Efficacy and Safety of Artemisininnaphthoquine versus dihydroartemisinin-piperaquine in adult patients with uncomplicated malaria: a multi-centre study in Indonesia”. It is worth to add data safety and efficacy of …
Indonesia as a malaria endemic country is recommended to use Artemisinin-based Combination Therapy (ACT) for P. vivax malaria. Confirmation of Chloroquine resistant and ACT efficacy for P. vivax need to be investigated for supporting malaria treatment policy. Papua and East Nusa Tenggara (NTT) contribute the main malaria cases in Indonesia. To evaluate efficacy and safety of A…
Positive control of Plasmodium spp. is needed in identification of malaria species using Polymerase Chain Reaction (PCR) method. The limitedness of malaria positive control encourages us to develop the cloning method to multiply Plasmodium spp. DNA particularly P.vivax, P. malariae, and P. ovale that are still unable to be cultured continuously. DNA product of single round and nested PCR were u…
This study is part of the study with title "Monitoring drug resistance in subjects with P. falciparum and P.vivax malaria in Kalimantan and Sulawesi, Indonesia" which the objective to assess the efficacy and safety of Dihydroartemisinin - Piperaquine (DHP) in patients with malaria vivax in Kalimantan and Sulawesi. The design of study was a cross-sectional study and prospective evaluation of 87 …
Anemia merupakan salah satu dampak infeksi malaria falsiparum dan malaria vivaks. Respon imun ternyata mempengaruhi kadar hemoglobin. Sitokin proinflamasi dan antiinflamasi memainkan peranan penting terjadinya anemia penderita terinfeksi P. falciparum dan P. Vivax.Tujuan penelitian adalah untuk menilai hubungan antara kadar hemoglobin dengan sitokin TNFα, IFNγ, IL12 dan IL10 pada penderita ma…
Treatment failure in falciparum malaria may be caused by parasite resistant to antimalarial drug or new infection. Polymorphism genetic marker of P. falciparum namely MSP1, MSP2 and GLURP locus genes in the population should be identified as a baseline to distinguish the cause of treatment failure. A nested Polymerase Chain Reaction (PCR) method was applied to each locus gene separately. A tota…
Background: In 2007, in Indonesia 80% of a total 495 districts/municipalities was malaria endemic. Most malaria parasitemia is P. falciparum, and it is related to several risk factors. This analysis aimed to identify dominant risk factors related to P. falciparummalaria parasitemia among children 10 years or below. Methods: This analysis used a part of Basic Health Research year 2010 data. A…