Background: Since the last few decades, oral cancer as pathology has become an attention in medicine and dentistry. The majority cases of oral cancer are affecting people with smoking habit and alcohol consumption. Many herbs contain substances which can stop cancer cells proliferation, such as Piper retrofractum/Retrofracti fructus, an herb plant from Piperaceae family which contains piperin a…
Previous reasearch reported that chloroform extract that was partitioned from etanol exctracts of R. mucronata stem bark had sitotoxic against Myeloma cells (Diastuti, 2008). This research was aimed to fractinate the chloroform extract of R. mucronata stem bark and cytotoxicity test againts Myeloma cells, then identification the cytotoxic compounds. The ethanol extracts of R. mucronata steam ba…
Benzo (α) pyrene (BP) is a carcinogenic compound that is supposed to be able to indusce chromosomal damage. The mutagenic effect of BP has been studied using MN test on poly chromatic erythrocyte (PCE) cells of albino mice femur bone marrow. Mice were injected with 0.1 ml of 03% (b/v) BP subcutaneously at the sholder, every day at the same time for ten days. After 120 days, treated and non tre…