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The Effect of Norplant on Blood Clotting and Coronary Function (A Preliminary Study)

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Background: Hormonal contraceptives have been claimed to have an adverse effect on blood clotting because they make blood to clot more easily. In certain condition this leads to decrease in coronary function due to narrowing of its lumen or thrombus formation. Objective: To investigate weather Norplant after a certain period of use had side effects either in blood clotting profile or in coronary function. Design/data identification: A cross sectional study. Materials and method: Voluntary women consisting of 29 Norplant users and 28 IUD users, 30 to 50 years of age, having taken this method for at least four years, not obese, no history of hypertension nor heart disease were recruited. Plasma prothrombin time (PPT), activated partial thromboplastin time (APTT) and thrombocyte counts were blood clotting parameters being studied. Double master steps test was done as loading test to dectect the presence of coronary insufficiency. Results: Both groups were comparable in terms of body height and weight parity and hemoglobin content, but not for age and duration of usage. The mean age of IUD users (42.46 years) were somewhat higher than Norplant (38.29 years) and the mean duration of IUD use was much more langer than Norplant i.e. 163.71 months vs 69.37 months respectively. PPT for Norplant users was 13.28 plus/minus 0.85 seconds compared with 13.16 plus/minus 0.90 for IUD users (p more than 0.05) and APTT for Norplant users was 31.65 plus/minus 5.14 seconds compared with 31.18 plus/minus 4.89 seconds for IUD users (p more than 0.05). Platelet count for Norplant users was 373.62 plus/minus 54.13 thousands compared with 398.82 plus/minus 50.59 thousands for IUD user (p more than 0.05). The rate of positive double Master step test was not different i.e 20.68 percent compared with 22.22 percent for IUD users and the risk of getting positive double Master step test was 0.98 (95 percent CL 0.74-1.29). Conclusion: The study concluded that during about five years of use Norplant had no harmful effect on blood clotting and coronary function.

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Majalah Obstetri dan Ginekologi Indonesia,20(4)199

Publisher

: ., 1996

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contraceptive devices, female

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