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The Effects of Vitamin A Administered Orally on the Kinetics of 7 S and 19 S Classes Specific Antibodies in Rats (Vitamin A dan Imunitas : Pengaruh Pemberian Oral terhadap Titer Antibodi Anti-sel Darah Merah Domba Kelas 7 S dan Kelas 19 S pada Tikus)

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Previous report showed that vitamin A increased rats specific anti-sheep red blood cells (SRBC) antibodies titres and maintained the levels for a relatively long period. In the following study, we observed the effects of vitamin A, administered orally, on the kinetics of 7 S and 19 S classes specific antibodies in rats. Twenty males Wistar rats were divided randomly into 4 groups of equal number. Group 1 received no treatment and served as a control group. Group II immunized with SRBC while III, beside the immunization, received a certain amount of vegetable oil, which was the medium used A solvent. The group IV received, besides the imunization, a dose of vitamin A. The vegetable oil and the vitamin A were given orally, one hour after the immunization. They were done by an intraperitoneal injection. Blood from each rat were collected from the tail weekly, for a period of 12 weeks successively. The titres of total anti-RSBC antibodies were assesed based on a hemaglutination reaction. The titres of the 7 S class anti-SRBC antibodies were assesed in the same way, after the reduction of the serum with 2-mercaptoethanol (ME). We found that vitamin A increased the titres of the 7 S class anti-SRBC antibodies earlier than the others groups and maintained the titres at a relatively high levels for 12 weeks. The results suggested that vitamin A, given orally, could influence the switch of 19 S class antibodies into 7 S.

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Majalah Kedokteran Indonesia,46(11)1996:599-604

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: ., 1996

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vitamin a
rats

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