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Principles of Signal-Transduction Therapy Applied to Cancer (Penerapan Dasar Pemikiran Transduksi Sinyal pada Penanggulangan Kanker)

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Great progress in molecular biology and medicine has made it possible to develop a novel, more selective chemotherapy based on signal-transduction principles. Signal-transduction pathways are identified by the cell as a device for the control of metabolism and proliferation. The transformation of a normal cell to a cancer cell is a complex multistep process. It is clear that hyperproliferation and failure to differentiate are in consequence of a total breakdown of intracellular signaling system. Cancer cells are highly dependent on aberrant biochemical pathways, lacking the capacity of normal cells to sustain sudden shocks. This is what makes cancer cells vulnerable to attack. Many biochemical processes participating in carcinogenesis involve Ca2+ as signaling elements. The crucial involvement of Ca2+ was the underlying reason to attempt prevention of tumor growth and migration by blocking Ca2+ dependent pathways with chemoattractants. Carboxamide amino-imidazole has been through clinical trials and reveals signs of good prospects and no toxic effects on normal cells.

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Majalah Kedokteran Indonesia,46(10)1996:581-585

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: ., 1996

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neoplasms

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