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Immunogenetic Aspects of Systemic Lupus Erythematosus/SLE (Aspek Imunogenetik Penyakit Systemic Lupus Erythematosus/SLE)

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Over the last two decades, it has been issued that genetic factors were important role in the actiopathogenesis of lupus erythematosus. At the same time, the development of informations regarding the highly complex genetic control of immune response made the association of SLE with actual genetic marker, become more obvious. Most notably were the increased frequencies of certain human leucocyte antigens (HLA), encodes from Major Histocompatibility Complex (MHC) in patients with SLE. Additionally, hereditary deficiences of early component of the complement system, several of which also mapped to the MHC were found to increase disease suspectibility. There also have been enormous advances in understanding of the structure and function relationship among MHC and T cell receptor in the development of immunotherapeutic strategis for the treatment of the autoimmune disease. Basically, the autoimmune disease is so called immunologic suicide where the body destroy its own tissue. The concept is now envolving that SLE is a multigenic complex disease with highly diversity, which creates several overlapping autoantibody profiles. The purpose of this paper to describe the structures and functions of those genetic system, which are currently most relevant to immune mechanism of SLE.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Majalah Kedokteran Indonesia,46(10)1996:575-580

Penerbit

: ., 1996

Deskripsi Fisik

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Bahasa

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

lupus erythematosus, systemic

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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