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Effect of the Semisolid Formulation Variation of Diclofenac Sodium through its Percutaneous (Pengaruh Variasi Formula Semi Solid Natrium Diklofenak terhadap Absorpsi Perkuatan dan Korelasinya secara in Vitro - in Vivo)

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Diclofenac sodium is a nonsteroidal antiinflammatory drug (NSAID), which is drug of choice for rheumatoid arthritis. It is comercially available as enteric coated tablet and emulgel for topical dosage form. Topical drug was prepared and developed for systemic purposes in the treatment of rheumatoid arthritis, to reduce the risk of adverse drug reaction given orally. As an oral antirheumatoid drug, it caused dizziness and irritation on gastric mucosa. The study was carried out to assess the effect of semisolid formulation variation on its percutaneous absorption. The experiment was performed by preparing 4 formulas of ointment i.e. hydrocarbon base, washable base, O/W emulsion base, W/O emulsion base and commercial cream E as a control drug. All of the formulas and standard cream were tested in vitro for the rate of dissolution and its percutaneous absorption on rabbits. The Dissolution Efficiency (DE) of washable emulsin, O/W emulsion base, and the commercial cream was correlated with their Ka from the experiment of percutaneous absorption. Among the three formulas, the C ointment (O/W emulsion Base) showed the best correlation. The order of the correlation declined as follows C, B and E. From the result it can be concluded that the change of formulation could effect the dissolution and in turn could effect the absorption of the active compounds.

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Berkala Ilmu Kedokteran,28(1)1996:27-33

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: ., 1996

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diclofenac

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