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Antiphospholipid Syndrome (Sindrom Antibodi Antifosfolipid)

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Antiphospholipid syndrome (APS) is a disorder of recurrent vascular thrombosis, pregnancy losses and thrombocytopenia associated with persistently elevated levels of antiphospholipid antibodies (APA). Many patients with APS have clinical and laboratory features found in other autoimmune diseases, particulary SLE. Such patients should be defined as having a 'secondary' APS to distinguish them from patients with features of APS alone ('primary' APS). The relationship of APA to thrombosis and pregnancy loss is unknown. The antibodies may be just 'marker' of the disorder, and thrombosis and pregnancy loss may results from unknown factors which induce a proagulant state. Alternatively, the antibodies may contribute directly to a procoagulant state. Among the proposed mechanism by which APA might cause thrombosis, investigators have considered effects on vascular endotheliums, platelets, and on proteins of the clotting cascade. The management of venous or arterial thrombosis in patients with APS is no different from that of other patients with similar complications. However, since APS patients appear more subject to recurrent events, prophylactic treatment is recommended for a prolonged period of time. The management of women with APS during pregnancy has generated considerable controversy since they may have a significant chance of succesful pregnancy outcome without treatment.

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Majalah Kedokteran Indonesia,46(8)1996:447-456

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: ., 1996

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antiphospholipid syndrome

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